Virology-paramyxoviruses | quick Revision Notes for NEET-PG

MumpsMC cause of parotid gland enlargement in childrenPathogenesisTransmission is through the respiratory route via droplets, saliva, and fomites-----------> virus causes primary infection in nasal and upper respiratory mucosa-------------->infects mononuclear cells and regional lymph nodes------------->spills over to bloodstream-------------> causes viremia------------> dissemination------------> mumps virus has special affinity for glandular epithelium of salivary…

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Virology- Rhabdoviruses | Quick Revision Notes for NEET-PG
Negri bodies in brain of a patient suffering from Rabies

Virology- Rhabdoviruses | Quick Revision Notes for NEET-PG

Rabies virus Rapidly progressive acute infectious disease of CNS  in human and other animals It has a unique morphology Bullet shaped 10nm long spikes of glycoprotein-G embedded in the Lipid envelope. This envelope is lined internally with a layer of matrix proteins Helical nucleocapsid with  -sense ssRNA Rabies only has…

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Mycology-Superficial Mycoses | Detailed Revision Notes for NEET-PG
Microsporum gypseum( LPCB mount)

Mycology-Superficial Mycoses | Detailed Revision Notes for NEET-PG

Tinea Versicolor Superficial fungal infection involving stratum corneum of the skin caused by Malassezia furfur C/F Commonly occurs in a humid environment Flat round scaly patches of hypo to hyperpigmented skin Non-inflammatory lesions Lab Dx Collect skin scrapings-------->treat with 10% KOH-------->budding yeasts with septate hyphae seen                                                                                                                 (spaghetti and meatball appearance)…

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Mycology-Lab Diagnosis | Detailed Revision Notes for NEET-PG

Specimen collection Hain/nail/sputum/skin scrapings/blood or CSF (depends upon site of infection) Microscopy                                                                                                 10% glycerol to prevent drying Keratinized tissue specimen + 10% KOH--------------------------------------------------> keratin digested and      ( skin scraping or hair)      (20-40% for nails and biopsy tissue)                               clear fungal hyphae seen Gram staining Yeast and yeast-like fungi +…

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Bacteriology- Clostridium | Quick Revision Notes for NEET-PG

Gram-positive spores and toxin-producing anaerobic bacillusMotility present except inC. perfringes(C.welchi)C. tetani type VICapsule present in C. perfringensC. butyricumC. perfringens(welchi)Capsulated non-motile organisms which produce oval spores present sub-terminallyStormy fermentation on litmus milk mediaLitmus milk media (differential media)contains-Skimmed milk(W/o Fat) containing sugar(Lactose) & protein (casein-milk protein)Litmus indicatorC. perfringens show stormy fermentation in…

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Bacteriology-Bordetella | Quick Revision Notes for NEET-PG

Bordetella pertussis Strict aerobe Gram-negative rods Non-motile and non-sporing(Exception-Bordetella bronchiseptica is motile) Capsulated Causes whooping cough/Pertussis/childhood cough Obligate intracellular parasite Virulence factor and pathogenesis -Pertussis toxin/exotoxin causes ADP ribosylation of G protein>increase cAMP in cell>edema>irritation>Intense coughing.It also induce lymphocytosis Fimbrial Ag-helps in attaching to cell Adenylate cyclase Tracheal cytotoxin LPS/endotoxin…

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Bacteriology-Shigella | Quick Revision Notes for NEET-PG

Gram-negative non-sporing ,non-motile & non-capsulated organism Ferments glucose producing acid but no gas(amerogenic) Non-lactose fermentors except S. Soneei which is a late lactose fermentor On the basis of mannitol fermentation & somatic O polysaccharide antigen, it is divided into 4 groups Mannitol fermentors -S. dysenteriae(group A) Mannitol non-fermentors-S. flexneri(group B),S.…

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Bacteriology-Escherichia coli | Quick Revision Notes for NEET-PG

Gram-negative rods, non-capsulated(some capsulated-pathogenic)motile by peritrichous flagella with 80% strains possessing flagella Commensals in the gut(MC-Bacteroides fragilis-Anaerobic) Gut flora- anaerobes v/s aerobs - 1000:1 Indole +ve MethylRed+ve VP(Voges Praus) test -ve Citrate test -ve Ferments glucose-produce acid and gas Diarrhoeagenic E. Coli - 6 types EPEC(Enteropathogenic E. coli) ETEC(Enterotoxigenic E.…

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