Pseudomonas aeruginosa is a Gram-negative strict aerobic bacillus motile by a polar flagellum
It is catalase and oxidase positive
It is the important causative agent of Nosocomial/hospital-based infections(Nosocomial is a Greek word which means Hospital)
It grows in selectively on cetrimide agar
Produce non-lactose fermenting(colorless) colonies on McConkey’s agar.
It produces 2 important pigments
These pigments are The most. Hence, they are responsible for Blue and green color of colonies and culture medium
A fruity odor of colonies is due to ketones
Capsule/mine layer-inhibit phagocytosis
LPS/endotoxin-causes septic shock in infected individuals
Exotoxin A-It inhibit protein synthesis(Same MOA is seen in Diphtheria toxin)
It is the most common cause of Burn Wounds. Bacteria colonize the GIT reach the skin and causes colonization of eschar leading to cellulitis(BLUE-GREEN pus).So, careful housekeeping and restricted diet are required in burn units in hospitals.
The most common cause of keratitis in contact lens users
Cause swimmer’s ears(mild otitis externa)
Causes Malignant otitis externa in Diabetic patients
Causes Nosocomial pneumonia
Pneumonia and septicemia in neutropenic patients
An important cause of pneumonia in patients suffering from cystic fibrosis (such strains are biofilm producers)
Causes Urinary tract infection, especially in catheterized patients
Causes endocarditis in intravenous drug abusers where rt heart valves are affected.
Reservoir-ubiquitous in water
Mode of transmission-water aerosols, vegetables, flowers.
Drug resistance in P. aeruginosa
Plasmid acquired resistance mediated by beta-lactamases and acetylating enzymes.